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Before your first injection, check that the pen is not expired and has been stored correctly

Anh-Tuan Truong With over 23 years of experience and triple board certification , Dr

Van Biesen, W., Lameire, N., Vanholder, R

On semaglutide, where nausea can be a factor, starting with the lower steady-state approach and avoiding large single doses is generally more comfortable

These are the factors that typically point toward the slower path: Prior intolerable nausea or vomiting on semaglutide, tirzepatide, or other GLP-1 medications History of GERD, gastroparesis, or functional GI disorders Lower body weight, where the effective dose-per-kilogram is relatively higher at standard doses First-time users of peptide or GLP-class medications with no tolerability baseline The slow-titration approach does not change the target dose or the expected outcomes

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