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If total weight loss is the priority, begin with semaglutide or tirzepatide

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Although the individualized role of GM in AADs metabolism is not fully recognized, some information could be proposed from the chemical structure and the pharmacokinetics properties of the AADs (shown in Table 1)

The 0.25mg starting dose generally produces fewer gastrointestinal symptoms than higher doses, making long-term tolerance easier for many patients

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