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The landmark STEP 1 trial ran for 68 weeks, reflecting that semaglutide is a long-term treatment programme, not a rapid intervention

How Im applying the pharmacotherapy recommendations in clinic 1) Start with expected placebo-subtracted weight loss (beyond lifestyle) ADA groups AOMs by average magnitude of benefit and reminds us: total effect = AOM + lifestyle (and intensive behavioral programs can amplify outcomes)

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Protein expression was induced by addition of 0.1 mM IPTG and cultured for an additional 16 18 hrs at 25 C