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Women on calorie-restricted diets frequently develop subclinical zinc deficiency within months

Repeated injections in one location can cause lipohypertrophy (thickened fatty tissue) or lipodystrophy, which affects peptide absorption and creates visible bumps

In the SURMOUNT-1 trial, tirzepatide produced dose-dependent weight reductions, with average losses approaching or exceeding ~20% at higher doses in adults with obesity who did not have diabetes, numbers that markedly exceed historical pharmacotherapy benchmarks

Constipation affected approximately 18% of women and 14% of men

Retatrutide dosing is designed for once-weekly administration due to the compounds 5-7 day half-life

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