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6.1.3 Combination therapy Studies have shown that combining PHGDH inhibitors with serine/glycine-restricted diets yields synergistic antitumor effects

Most patients notice reduced appetite within days to weeks, while blood sugar improvements typically begin within 12 weeks

Lancet 2012;379:1403-1411

Consistent use as prescribed is key to achieving results

Some nutrients drop faster than others on GLP-1 therapy

Single-label FISH for Glp1r or Gcg Spinal cord cryosections collected at 1 mm interval were hybridized with digoxigenin-labeled riboprobes for Glp1r (corresponding to 11-1402 of the mouse Glp1r mRNA, Genbank # NM_021332.2) 60 or Gcg (corresponding to 75-944 of the mouse Gcg mRNA, NM_008100.4)