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It is a more accountable path

The yeast pantothenate kinase Cab1 is a master regulator of sterol metabolism and of susceptibility to ergosterol biosynthesis inhibitors

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In clinical practice, it is often a combination of catastrophe

Rapado-Castro M, Dod S, Bush AI, Skvarc DR, On ZX, Berk M, Dean OM, et al

Toxicol Lett 245:7885 Kim J-H, Baek J-I, Lee I-K, Kim U-K, Kim Y-R, Lee K-Y (2022) Protective effect of berberine chloride against cisplatin-induced ototoxicity