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Since sperm contain only a small amount of cytoplasmic antioxidants, most of the cytoplasm has been shed

Contact your GP or prescriber if constipation persists despite lifestyle measures for 12 weeks, or immediately if you experience severe abdominal pain, inability to pass stools or wind, rectal bleeding, persistent vomiting, or signs of bowel obstruction

Grotto et al., 2009

Individuals with significant kidney impairment might be advised to use alternative forms to cyanocobalamin as a precautionary measure, though evidence of clinical harm at standard supplementation doses is lacking

New York, US: Wiley-Interscience

moreover the situation is complicated by the tendency of the iodixanol molecules to associate non-covalently in a concentrated aqueous solution