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So for every couple planning to get pregnant, it is vital that male fertility is addressed and sperm is protected from free radical damage before conceiving

PLoS ONE 6 , e18173 (2011)

Furthermore, systemic induction of RCD can provoke excessive inflammation and collateral tissue damage, leading to adverse effects such as cytokine release syndrome or organ toxicity (162)

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Interestingly, metabolic disorders and elevated oxidative stress disturb the insulin-associated signaling within the ovary and can dysregulate the dynamics of the ovarian function through the impair the ovarian reserve, survival, and quality of the eggs [15]