Body weight and food intake did not significantly differ between the HCD and HCD + ALC groups (Figures 4D,E)
2026 Update: In the SURMOUNT-5 head-to-head trial, tirzepatide produced ~47% more weight loss than semaglutide over 72 weeks
For safety outcomes, the results for tirzepatide were generally similar to both semaglutide and liraglutide
NAFLD encompasses a disease spectrum ranging from simple steatosis to steatohepatitis (defined histologically as hepatocyte injury due to inflammation and hepatocellular ballooning), liver cirrhosis and hepatocellular carcinoma
The following are potential risks of biweekly dosing: The return of food noise The half-life of semaglutide is approximately 7 days, which means the concentration of semaglutide in the blood remains half after this period
The evidence is encouraging but modest, and it points one way: selenium helps most in men who start out short of it