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In humans and rodents, GIP infusion results in decreased levels of cross-linked C-terminal telopeptide of type I collagen (CTX-1) and increased levels of procollagen type I N-terminal propeptide (P1NP), regardless of whether blood glucose levels are normal or elevated [50,51,52]

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Hence, it can be concluded that fetal metformin concentrations closely mirror those found in maternal circulation

That said, one 2010 study did not find sufficient data to conclude that insufficient iron status was the primary reason for the low plasma carnitine levels observed in pregnant women

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