The terminal reaction of cholesterol synthesis, the conversion of 7-dehydrocholesterol to cholesterol, is catalyzed by the NADPH -requiring enzyme, 7-dehydrocholesterol reductase (encoded by the DHCR7 gene)
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They bypass the gastrointestinal tract and directly enter the bloodstream, assuring the more rapid delivery of vitamin B12
Compared with overt Cushings syndrome, patients with MACS exhibit similar but less pronounced phenotypic features, including abdominal adiposity, dorsocervical fat accumulation, characteristic skin changes, and proximal muscle weakness [177]
Interestingly, MRAB urine and skin isolates must contain significant levels of protein integrated within their biofilms, as evidenced by Proteinase K treatment (Figure 3B)
Cassandra Mackey, MD (Assistant Professor of Emergency Medicine, UMass Chan Medical School)