However, metformin treatment ameliorated astrocyte activation in the dopamine-depleted striatum (Ryu et al., 2020)
& Chuang, Y.-C
doi: 10.1016/j.ejcb.2022.151249 104 RuffmannR.WendelA
Katila N, Bhurtel S, Shadfar S, Srivastav S, Neupane S, Ojha U, Jeong GS, Choi DY (2017) Metformin lowers -synuclein phosphorylation and upregulates neurotrophic factor in the MPTP mouse model of Parkinson's disease
DOPAL has been found to cause cell death in vitro 10 and in vivo 11 , cause -synuclein aggregation and adduct formation 12 , disrupt neurotrophic cell signaling, and stimulate reactive oxygen species (ROS) generation and protein cross-linking 13,14
Dosage 1 capsule, two times a day after meals