Lipotoxicity can also further induce ER stress, impair autophagy and promote aseptic inflammatory responses, thereby exacerbating hepatocyte injury and death (59,60)
It is a target gene of the nuclear receptors peroxisome proliferator-activated receptors (PPAR)- and PPAR- (Liu et al., 2017
Clinical implication: clinicians should treat vaginal symptoms in patients taking semaglutide as real and addressable , but approach causality cautiously: prioritise common diagnoses (genitourinary syndrome of menopause, infections, dermatologic vulvar disease, STIs, irritant/contact dermatitis, pelvic floor disorders), identify important confounders (notably SGLT2 inhibitors, antibiotics, hormonal therapies), manage symptoms and underlying conditions, and report suspected adverse reactions when there is a reasonable temporal relationship and alternative causes are less likely
Tirzepatides 10 kilograms again led the field
Researchers forecast average health care costs to rise 9% in 2026
Fish, particularly salmon, cod, and tilapia, provides high-quality protein with omega-3 fatty acids