105 , S117S314 (2024)
It leads to changes in the structure of skin matrix proteins, such as collagen and elastin, and consequently, to loss of skin elasticity and firmness, the formation of wrinkles, and pigmentation disorders (116118)
The dose may be further adjusted based on your blood sugar response
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The study employed a dose-escalation protocol to mitigate gastrointestinal side effects: Weeks 04: 2 mg once weekly (for groups escalating to 4 mg, 8 mg, or 12 mg) Weeks 58: 4 mg once weekly (for groups escalating to 8 mg or 12 mg) Weeks 912: 8 mg once weekly (for the 12 mg group only) Weeks 1348: Maintenance dose (4 mg, 8 mg, or 12 mg depending on group assignment) This gradual escalation reduced the incidence and severity of nausea compared to immediate initiation at higher doses
