However, there is no consensus on whether this SNP confers a gain- or loss-of-function, with contradicting findings on its effects on T cell activation (7073)
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Secondary endpoints included alterations over the 24-week period in physical assessments, such as body weight, body mass index (BMI), and blood pressure, as well as metabolic parameters, including liver enzymes, renal function, urine albumin excretion ratio (UACR), lipid profile, and uric acid levels
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Equally important is a thorough regulatory due diligence at the pre-market stage, as gaps in product characterisation, safety data, or substantiation strategy can significantly increase the risk of costly delays, requests for additional information, or ultimately a negative regulatory outcome
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