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Although diabetes is widely accepted as one of the major risk factors for cardiovascular disease, the cardiovascular safety of antidiabetic drugs has been questioned due to the finding that intensive glycemic control by antidiabetic medications may result in an unexpected increase in cardiovascular death under certain circumstances [6]

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This genome replicated in cell culture and produced robust levels of infectious virus (HCVcc), nearly 10 5 infectious units ml 1 within 48 h in Huh-7.5 cells, which are highly permissive for HCV RNA replication 99

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