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2017 Sep;47(9):2733-2742

Wang SY, Wu SL, Chen TC, Chuang CS

Advances in therapy, 38(6), 28212839

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Much evidence suggests that the deficiency of this hormone increases insulin resistance, impairs lipid metabolism, augments oxidative damage and deregulates the neuro-hormonal axis

These findings provide direct genetic evidence that variation in the drug target genes contributes to inter-person variability in response and lay the foundation for precision medicine approaches in the treatment of obesity