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Okabe K, Yaku K, Uchida Y, et al

In contrast, no significant improvement of IL-1, IL-6, IL-10, TNF-, IL-4, IL-12p70, IL-17 A, IFN-, granulocyte-macrophage colony-stimulating factor (GM-CSF), IL-8, IFN-inducible protein-10 (IP-10), macrophage inflammatory protein-1 (MIP-1), monocyte chemoattractant protein-1 (MCP-1), vascular endothelial growth factor (VEGF), and leukocyte count could be observed following the oral application of a single high dose of 200,000 IU cholecalciferol in hospitalized patients with moderate to severe COVID-19 (55.5 14.3 y/o) [190]

Further, the periodic introduction of decreased maintenance doses during 2-3 months or for life is possible

Drug Interactions No specific drug interactions have been documented for BPC-157

It dehydrates tissue and diverts liver resources toward ethanol metabolism