intramuscular route: count injections given Visit 3 (week 26) Anamnesis: record lifestyle habits and use of alcohol Symptoms: if pathological at the first visit, record paresthesia, asthenia, loss or reduction of appetite, sadness or change in level of happiness, and concomitant pharmacological treatment Physical examination: if pathological at the first visit examine for Hunters glositis, positional and vibrational sensitivity Record concomitant treatment Request analyses to be performed one week before next visit: haemogram and serum vitamin B12 Questionnaire: EuroQoL-5D Assessment of adverse effects Therapeutic plan: patient in oral arm provision of medication
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The trial found significant weight loss across all treatment groups, with the highest dose producing the largest effect
Janosik M, Kery V, Gaustadnes M, Maclean KMN, Kraus JP: Regulation of human cystathionine beta-synthase by S-adenosyl-L-methionine: Evidence for two catalytically active conformations involving an autoinhibitory domain in the C-terminal region
