Moreover, in an in vitro model of blast-induced auditory hair cell damage, 3-AB inhibition of PARP1 reduced oxidative stress markers, upregulated antioxidant defenses, and helped maintain cell viability by preserving ATP pools 175
Cuprizone-induced demyelination in animals is commonly accepted for studying multiple sclerosis-related lesions and is characterized by degeneration of oligodendrocytes more than by a direct attack on the myelin sheet [31]
Confounding factors: Natural disease fluctuation, seasonal variations, medication changes, other health changes (new diabetes diagnosis, blood pressure changes)
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In addition, some investigators found that USP22 and lncRNA PART1 expression was decreased in a MIR injury model
