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Weight cycling, a scenario likely in real-world GLP-1 therapy use due to treatment discontinuation and subsequent weight regain, further increases this risk, as repeated cycles of weight loss and regain are associated with cumulative muscle loss and progressive declines strength [25]

The scientific record corrected itself in slow motion while the molecule shipped in fast envelopes, and the press-release number outlived the IPO, the trial, and the papers that were eventually pulled

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