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Key findings include: Upregulation of Shh pathway components in ischemic brain regions Enhanced neural stem cell proliferation and differentiation Improved angiogenesis supporting tissue repair Modulation of blood-brain barrier integrity The Shh pathway activation appears particularly relevant in stroke recovery models, where enhanced neurogenesis and vascular support correlate with functional improvements

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22 Based on the favorable bioavailability of the amide, N-acetylcysteine amide (NACA), over the acid, NAC, 23 and likely its methyl ester, 24 the pursuit of NACA therapy for treatment of HCCAA is warranted

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doi: 118

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