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There were extensive clinical trials on semaglutide before it was approved for public use

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(Bastyr University Research Institute, Seattle, WA, USA, 2013)

Gastrointestinal symptoms like abdominal pain, vomiting, nausea, diarrhea, and constipation are the most commonly reported adverse side effects of the medication

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Although homocysteine is naturally present in our bodies, too much homocysteine in the blood has been associated with an increased risk of CVD, including venous thrombosis, atherosclerosis, high blood pressure, coronary heart disease, and stroke