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Allen J, Romay-Tallon R, Brymer KJ, Caruncho HJ, Kalynchuk LE

A key mechanism is reducing excitotoxicity and oxidative stress during and after ischemic events

Effective across multiple GI pathology models including ulcers, fistulas, and inflammatory bowel disease No reported toxicity even at high doses in preclinical studies Mechanism involves interaction with NO system, dopamine system, and prostaglandin pathways The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration2011Tissue Repair BPC 157 accelerates healing of transected rat Achilles tendon and stimulates tendocyte growth in vitro

MK-677 (Ibutamoren) Bottom line: MK-677 is more convenient but creates continuous (not pulsatile) GH elevation and has more metabolic side effects

Batsis JA, Apolzan JW, Bagley PJ, et al