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For instance, in the past decades we have seen the optimum level for vitamin D increase, as we have more evidence that lower levels of vitamin D are associated with disease in the long term (e.g

Tyrberg M, Melander A, Lvestam-Adrian M, Lindblad U

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The authors also noted that further optimisation was needed, including work relating to high clearance in mice and off-target activity against monoamine oxidase A