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The peptide works both before and after alcohol exposure (Boban Blagaic et al., 2004)

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Hennessy KM, Clem WC, Phipps MC, Sawyer AA, Shaikh FM, Bellis SL

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This pathway is considered the most genotoxic as the 4-OH estrogen metabolites can become reactive quinones that have the potential to bind to DNA and form damaging (unstable) depurating adducts, that may increase risk for cancer, such as breast and prostate cancer