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The FDA-approved criteria for semaglutide (Wegovy) include adults with a BMI of 30 or greater (obesity), or adults with a BMI of 27 or greater (overweight) who have at least one weight-related comorbidity such as type 2 diabetes, high blood pressure, high cholesterol, or obstructive sleep apnea

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However, observational studies suggest that whilst acute toxicity remains exceptionally rare, sustained very high levels of B12particularly from supplements or injectionsmay be associated with certain health concerns, though these are correlations rather than proven causal relationships

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Can also be consumed on empty stomach.