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The mechanisms involved in the beneficial actions of GLP-1 receptor agonists on MASLD are indirect, given the virtual absence of GLP-1R in hepatocytes, except for those in T cells which are associated with anti-inflammatory effect.9 These include fat mass reduction, increased hepatic insulin sensitivity, reduced tissue lipotoxicity, anti-inflammatory effect and improved mitochondrial function32 (Fig

Key Background GLP-1 drugs, which were first designated for diabetes treatment, have become wildly popular in the last few years due to their effectiveness and FDA approval as a weight loss drug

10.1074/jbc.M507518200 J

Orthology clusters from gene trees with Possvm

Severe hepatotoxicity is rare, but case reports describe hepatitis and even liver failure

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