Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are medications primarily used to treat type 2 diabetes and, more recently, obesity
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Ultimately, the EPOs Board of Appeal (BoA) rejected this evidence as basis for establishing an unexpected technical effect of the claimed subject matter and emphasised that commercial success could not retroactively establish inventive step if the claimed features were already suggested by the prior art at the priority date
However, while GLP-1 RAs did not exhibit an increased risk of acute pancreatitis, DPP-4 inhibitors demonstrated a notable risk elevation (rate ratio, 1.75) [53]
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Dose Range: 5001000 mcg daily with gradual titration (~5 mg/week average)