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The dosing schedule is carefully structured over five months to reach the full maintenance dose: Months 1 (Weeks 1-4): Start with 0.25 mg once a week

Plasmid DNA was prepared using the Qiagen Plasmid Maxi Kit or GenElute HP Endotoxin-Free Maxiprep kit (Sigma) according to the manufacturers instructions

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OSAS/hypoxia acts as a trigger for localized hepatic oxidative stress and inflammation that promotes the progression of NASH and hepatic fibrosis [109, 110]

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