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doi:10.1016/0378-1119(94)90802-8

Since this is a rare condition, treatments may vary based on individual symptoms and severity

Molecules 15, 35073516

Opara EC, Petro A, Tevrizian A, Feinglos MN, Surwit RS

Hyperpigmentation: 4% niacinamide reduces melasma severity, and 5% formulations show tone improvement when paired with antioxidants and tranexamic acid

10.1016/j.brainres.2015.11.018 65 Lloyd-PriceJ.ArzeC.AnanthakrishnanA