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The choice between them depends less on absolute safety and more on individual patient factors: medical history, prior medication responses, gastrointestinal tolerance, and weight-loss goals

Nausea is the most commonly reported response in the first 24 hours, occurring in approximately 25% to 40% of patients starting semaglutide therapy

& Keating, D

Symptomatic and neurophysiological responses of paclitaxel- or cisplatin-induced neuropathy to oral acetyl-l-carnitine

1986 Sep;122(9):1054-6

Semaglutide is a GLP-1 receptor agonist, a class of medications originally developed for type 2 diabetes that demonstrated significant weight loss effects in clinical trials