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It also reduces the release of glucagon (a hormone that raises blood sugar)

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The first head-to-head clinical trial (SURMOUNT-5, published in NEJM 2025) showed tirzepatide produced 20.2% average weight loss at 72 weeks versus 13.7% for semaglutide approximately 47% greater relative weight loss

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Cancer may have spread to places in the skin far away from where it first started

[DOI] [PubMed] [Google Scholar] [15].Zhu T, Li C, Zhang X, et al