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MyD88-dependent signaling, either directly or via TIRAP, leads to the assembly of IL-1 receptor-associated kinases (IRAKs) and tumor necrosis factor (TNF)-associated factor 6 (TRAF6), thereby culminating in the phosphorylation of inhibitor B kinases (IKKs)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 10.Melndez-Hevia E., De Paz-Lugo P., Cornish-Bowden A., Crdenas M

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Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1