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Deficiency leads to methylmalonic acid accumulation, which can cause neurological damage over time

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Niacinamide (vitamin B3) supports metabolic function and has been studied for potential benefits in insulin sensitivity

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Meanwhile, several newly developed GPX4 stabilizers and expression enhancerssuch as KCF18 and ebselenhave shown neuroprotective effects in experimental settings (SharathBabu et al., 2025