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These multiple functionalities have contributed to the recent efforts to target GSTs with novel small molecule therapeutics

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Loss of GPX4 protein expression in NRF1-deficient cells sensitized cells to ferroptosis, whereas in cells lacking GPX4, overexpression of NRF1 failed to inhibit ferroptosis

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The consumption of aged garlic extract, a commercial garlic preparation that contains SAC, has been found to increase plasma SAC concentrations in humans (14-16)