Exercise capacity was determined by a single maximal exercise test to voluntary fatigue on a motorized treadmill (Exer 3/6, Columbus Instruments) in females [Young ( n = 10), Old Con ( n = 17), and Old mAb ( n = 22)] and males [Young ( n = 10), Old Con ( n = 9), and Old mAb ( n = 9)]
10.1096/fj.13-245472 178 RodriguesP.LimbackD.McGinnisL
Epithelial-mesenchymal transition (EMT) is a process in which epithelial cells acquire mesenchymal features [22, 23]
Chen J, Guo Q, Pei Y, Ren Q, Chi L, Hu R, et al
Induction and measurement of murine pulmonary fibrosis Pulmonary fibrosis was induced in female C57BL/6 mice (1012 weeks old) by a single intratracheal instillation of 50 l of bleomycin (3 U/kg, Sigma Aldrich, Taufkirchen, Germany) dissolved in sterile saline, and applied using the MicroSprayer Aerosolizer, Model IA-1 C (Penn-Century, Wyndmoor, PA)
This dual action, lowering destructive inflammation while boosting antioxidant defense, protects tissues from oxidative damage during aging and after injury (PMC3359723)