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Both drugs have meaningful GI side effects, and combining them outside a clinical trial could produce intolerable nausea or worse

Among non-human primates (NHPs), the highest GLP-1 immunoreactivity is present in the hypothalamus, the area postrema, the NTS, and the dorsal vagal nucleus (58, 59)

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But combinations require careful medical supervision to improve dosing and monitor for interactions

Thus, cell lysis is not needed

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