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1 mM/l glutamate de sodium et 10 mM/l BES (acide N,N-bis[2-hydroxythyl]-2-aminothanesulfonique).The nerve-muscle preparation is bathed in a modified Liley solution suitably oxygenated (95% O and 5% CO) at 37 o C, (137 mM / l NaCl

Keywords: diabetes, sitagliptin, Nrf2, Keap-1, miRNAs, GK rats Introduction Type 2 diabetes mellitus (T2DM) accounts for 90% of all cases of diabetes and constitutes the major single cause of end-stage renal disease (ESRD), which is a major cause of death and disability worldwide

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Leveraging this duality provides a conceptual framework for identifying redox-defined liabilities and developing next-generation therapies that exploit metabolic and oxidative imbalances in cancer and other diseases