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Gradual temperature transitions rather than sudden shifts

3.3 Molecular mechanisms of supraspinatus atrophy Supraspinatus atrophy in chronic rotator cuff tears (RCTs) results from disrupted protein homeostasis, neuromuscular impairment, inflammation, mitochondrial dysfunction, oxidative stress, and circadian rhythm dysregulation (Wan et al., 2022)

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Also investigated (29) was the effect of this intervention on neurophysiologic function that was assessed on the basis of peripheral nerve conductivity

Kappos et al., 2018

Either way, you'll work up gradually even if you were on a higher Zepbound dose to reduce the chance of side effects during the transition