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Creatine supplementation produced a small beneficial effect on cognitive outcomes in both groups, although significant differences between groups were not observed [89]

Exp Neurol 209:213223 Wang L, Yang HJ, Xia YY, Feng ZW (2010) Insulin-like growth factor 1 protects human neuroblastoma cells SH-EP1 against MPP+-induced apoptosis by AKT/GSK-3beta/JNK signaling

Concurrently, a clinical study involving 98 pSS patients and 105 healthy controls (208) found that butyrate-producing bacteria were significantly reduced in pSS patients, and this reduction correlated negatively with increased Th17 cells and an imbalance in Th17/Treg

Anal Chem 56:18901898 Kelly CP, Cramer CJ, Truhlar DG (2006) Aqueous solvation free energies of ions and ion-water clusters based on an accurate value for the absolute aqueous solvation free energy of the proton

Zhang et al., 2012)

Step Two: Is GLP-1 Therapy Medically Appropriate