In 2018, a 39 amino-acid peptide tirzepatide (LY3298176) was developed, which is similar in size to both GLP-1 and GIP with exenatide-derived C-terminal tail and thus has a prolonged half-life
doi:10.2337/dci24-0003
Traditional Antidepressants When we talk about treating depression, traditional antidepressants like SSRIs (Selective Serotonin Reuptake Inhibitors) and SNRIs (Serotonin-Norepinephrine Reuptake Inhibitors) have been the go-to for a long time
Seniors who pick up their first prescription this month are beginning an 18-month treatment course with no guaranteed path to affordable coverage when it ends
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Main causes: Ultra-processed food (low in fiber, high in simple sugars) Unbalanced gut microbiota (dysbiosis) Insulin resistance (prediabetes) Lack of sleep (reduces production by 30%) Chronic stress (cortisol inhibits GLP-1) Sedentary lifestyle Good news: Unlike your genetics, your GLP-1 production is completely modifiable by your lifestyle choices
