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It was designed at Monash University in Australia to isolate growth hormone's fat-metabolizing activity while stripping out everything else the growth-promoting effects, the IGF-1 elevation, the insulin antagonism, the fluid retention

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This can result in a slowed metabolic rate and increased fat storage

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Association of nicotinamide-N-methyltransferase mRNA expression in human adipose tissue and the plasma concentration of its product, 1-methylnicotinamide, with insulin resistance (in Eng)