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Using a reporter mouse to map known and novel sites of GLP-1 receptor expression in peripheral tissues of male mice

An increasing body of epidemiological evidence indicates that MPs can enter the body not only via relatively wide cutaneous routes such as hair follicles and sweat glands, but alsounder realistic exposure conditionsby penetrating the gastrointestinal barrier and reaching the circulatory system [13, 14]

The decrease in plasma glucose following pyruvate injection was abrogated with the administration of exendin-9-39, a compound that blocks signaling through the GLP-1R (35), 15 minutes before injection of pyruvate (Figure 2B)

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Greater proportions of patients treated with WEGOVY injection achieved 5%, 10%, and 15% weight loss than those treated with placebo as shown in Table 10

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