Retatrutide (also known as LY3437943) is an investigational medicine being studied for obesity and metabolic disease
Phase 3 trial data has now demonstrated weight loss outcomes that, in some patient groups, approach those previously only achieved through bariatric surgery
Eligibility is selective, with strict BMI, age, comorbidity, and previous-treatment criteria, and some participants receive placebo (a dummy version of the drug)
Further, T2DM remains one of the most significant risk factors not only for the development of MASLD but also for the progression of liver fibrosis and the occurrence of liverrelated complications, including HCC (Hosseinkhan et al., 2025
J., Sattar, N., Horn, D
Track ongoing studies and FDA progress What Is Retatrutide