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In an alcohol-instilled rat model, gastric, esophageal, and duodenal lesions develop alongside loss of left gastric artery vessel presentation

KPV acts directly on MC1R/MC4R receptors on macrophages and epithelial cells, reducing IL-6 and TNF- at the transcription level [7,8]

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That said, the animal research is genuinely interesting and points toward several areas worth continued investigation

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