Alterations in the gut microbiome have also been demonstrated in preclinical studies
By integrating metagenomic profiles, we further revealed that gut microbial dysbiosis in RBD-PD and iRBD drives a functional shift away from dietary fiber fermentation and toward enhanced degradation of protein, aromatic amino acids, glycine, and intestinal mucin glycans
The specific target, anti-tumor effect, and clinical progress of these inhibitors targeting NADPH metabolism are also summarized in Tables 1 and 2
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