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Separate phase III CVOTs of GLP1R agonists are currently being conducted in people living with heart failure with preserved ejection fraction and in those with obesity

The benefits often appear before weight loss occurs - cardiovascular risk drops within weeks, kidney function stabilizes, inflammation decreases, insulin sensitivity improves, and even osteoarthritis pain reduces as metabolic health improves

Cardiovascular and renal outcomes with Efpeglenatide in Type 2 diabetes

Month 3 and beyond: Patients who respond tend to continue responding