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Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of cardiac function

Enhancing mitochondrial proteostasis reduces amyloid- proteotoxicity

ABT-737 targets intrinsic apoptosis during cooperation of bcl-2 and oncogenic NRAs in an in vivo progression model of myelodysplasia/acute myeloid leukemia

When administered alone, MitoQ increased neuronal differentiation of MNA NB cells, suggesting a transition towards a more favorable phenotype

Glutarate is formed by the conversion of 2-oxoadipic acid to glutaryl-coenzyme A (glutaryl-CoA) within the mitochondria

The addition of B12 may reduce severity, though individual responses vary