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A pooled analysis of the STEP 1 through STEP 3 trials, published in Diabetes, Obesity and Metabolism in 2022, examined once-weekly semaglutide 2.4 mg in 2,117 participants against 1,262 on placebo

The evolving role of statins in the management of atherosclerosis

J.Ahnfelt-RnneJ.AlanentaloT.BaqueroA

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Common contributing factors include: Chronic constipation and straining during bowel movements Prolonged sitting on the toilet Diarrhea and frequent bowel movements Increased intra-abdominal pressure Given that Zepbound commonly causes both constipation (in approximately 16-17% of patients) and diarrhea (in about 18-24% of patients), these gastrointestinal effects could theoretically contribute to hemorrhoid development or worsening in susceptible individuals